Vol. 86, No. 5, May 2006, p. 762
Letters and Responses |
In Vitro Model of Cell Migration
In their response to my commentary on their article "Periodic Direct Current Does Not Promote Wound Closure in an In Vitro Dynamic Model of Cell Migration" (January 2006), Godbout and Frenette wrote, "The arguments of Dr Spielholz...are based on one misleading assumption that electrical stimulation is undoubtedly useful to heal wounds and that no other study, particularly in vitro, should be performed to improve our understanding of the complex mechanisms of healing under an electrical stimulation." This misrepresents what I said. I wrote, "I am not arguing against this in vitro preparation. When used and interpreted appropriately, it is indeed a unique method for studying how controlled perturbations of artificial environments may affect cell migration." Later, I specifically stated in my conclusion that "... my major disagreement with this article is not that it reports nonmigration of fibroblasts in a DC field, but that it states a clinical conclusion based on an in vitro model that does not mimic wound closure or wound healing. Generalizations that reach far beyond the methods are not only inappropriate but also may be misleading."
PT 2006 Attendees Join Physical Therapy’s New Editor in Chief and Editorial Board at a Session for Readers, Authors, and Reviewers* Taming Scorpions: How to Tell if a Clinical Study’s Results Are Important OR, The Dreaded Change Score You can’t know whether results are important—and relevant to practice—without statistics that give you the full story. For most people, however, reading about "confidence intervals," "effect size," and (worst of all) the "standard error of measurement" is like being dragged through a nest of scorpions. Fearless PTJ Editor Dan Riddle steps into the fire and explains it all to you, including hot new statistics like the MCID (minimal clinically important difference). Never get stung by statistics again! An openended discussion period follows, with Editor in Chief Rebecca Craik and PTJ’s new Editorial Board. Get comfortable with:
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nspielhoz{at}adelphia.net
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Physical Therapy 2006 86: 59-62.
Physical Therapy 2006 86: 63-65.
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